Genotoxicity gonads histology liver silver nanoparticles zebrafish.īruna T., Maldonado-Bravo F., Jara P., Caro N. Based on the results, it can be concluded that exposure to AgNPs causes cytotoxic changes in zebrafish, activates the immune system, negatively affects the process of meiosis in the gonads, and generates oxidative stress. Furthermore, AgNPs were found to interfere with spermatogenesis and oogonesis as well as reduce the expression levels of the cat, gpx1a, and sod1 genes in the liver compared with the control group. The highest proliferation index of hepatocytes was found in the AgNP 0.05 mg/dm 3 group. The histological analysis showed that AgNPs and silver ions cause an increase in the area of hepatocytes. On the last day of the experiment, the lowest survival rate was found in the AgNPs 0.05 mg/dm 3 group. In the liver, we analyzed the expression of the cat, gpx1a, gsr, sod1, and cyp1a genes. On the last day, the liver, testes, and ovaries were subjected to a histology analysis. Sexually mature zebrafish were exposed for seven days to silver ions (0.01 mg/dm 3) or AgNPs (0.01 0.05 0.1 0.5 1.0 mg/dm 3). The aim of the study was to determine the short-term exposure effects of AgNPs coated by PvP (polyvinylpyrrolidone) on the homeostasis of livers and gonads in zebrafish. Silver nanoparticles (AgNPs) are found in open waters, but the effect of their low concentrations on an organism's homeostasis is not fully understood.

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